Research on the Ingredients in BP Dove

Vitamin K2 and Blood Pressure (3 Clinical Trials)

  1. Knapen MH, Braam LA, Drummen NE, Bekers O, Hoeks AP, Vermeer C. Menaquinone-7 supplementation [promotes arterial health] healthy postmenopausal women. A double-blind randomised clinical trial. Thromb Haemost. 2015 May;113(5):1135-44. doi: 10.1160/TH14-08-0675. Epub 2015 Feb 19. PMID: 25694037.
  2. Fulton RL, McMurdo ME, Hill A, Abboud RJ, Arnold GP, Struthers AD, Khan F, Vermeer C, Knapen MH, Drummen NE, Witham MD. Effect of Vitamin K on Vascular Health and Physical Function in Older People .…--A Randomised Controlled Trial. J Nutr Health Aging. 2016 Mar;20(3):325-33. doi: 10.1007/s12603-015-0619-4. PMID: 26892582.
  3. Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83. doi: 10.1182/blood-2006-08-040709. Epub 2006 Dec 7. PMID: 17158229.

Vitamin C and blood pressure (48 Human Trials)

  1. Mason SA, Rasmussen B, van Loon LJC, Salmon J, Wadley GD. Ascorbic acid supplementation [promotes postprandial blood sugar and blood pressure health]: Findings of a randomized cross-over trial. [Dia] Obes Metab. 2019 Mar;21(3):674-682. doi: 10.1111/dom.13571. Epub 2018 Dec 2. PMID: 30394006.
  2. Barak OF, Caljkusic K, Hoiland RL, Ainslie PN, Thom SR, Yang M, Jovanov P, Dujic Z. Differential influence of vitamin C on the peripheral and cerebral circulation after diving and exposure to hyperoxia. Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R759-R767. doi: 10.1152/ajpregu.00412.2017. Epub 2018 Jul 11. PMID: 29995458.
  3. Hodgson JM, Croft KD, Woodman RJ, Puddey IB, Bondonno CP, Wu JH, Beilin LJ, Lukoshkova EV, Head GA, Ward NC. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials. Br J Nutr. 2014 Nov 14;112(9):1551-61. doi: 10.1017/S0007114514002542. Epub 2014 Sep 19. PMID: 25234339.
  4. Plotnick MD, D'Urzo KA, Gurd BJ, Pyke KE. The influence of vitamin C on the interaction between acute mental stress and endothelial function. Eur J Appl Physiol. 2017 Aug;117(8):1657-1668. doi: 10.1007/s00421-017-3655-4. Epub 2017 Jun 13. PMID: 28612123.
  5. Fernandes PR, Lira FA, Borba VV, Costa MJ, Trombeta IC, Santos Mdo S, Santos Ada C. Vitamin C [promotes healthy blood pressure and arterial function] during mental stress in obese children. Arq Bras Cardiol. 2011 Jun;96(6):490-7. English, Portuguese, Spanish. doi: 10.1590/s0066-782x2011005000057. Epub 2011 May 6. PMID: 21552645.
  6. de Oliveira IJ, de Souza VV, Motta V, Da-Silva SL. Effects of Oral Vitamin C Supplementation [on Promoting Calmness in Students]…: A Double-Blind, Randomized, Placebo-Controlled Trial. Pak J Biol Sci. 2015 Jan;18(1):11-8. doi: 10.3923/pjbs.2015.11.18. PMID: 26353411.
  7. Goldstein BH, Sandelin AM, Golbus JR, Warnke N, Gooding L, King KK, Donohue JE, Yu S, Gurney JG, Goldberg CS, Rocchini AP, Charpie JR. Impact of vitamin C on endothelial function and exercise capacity in patients with a Fontan circulation. Congenit Heart Dis. 2012 May-Jun;7(3):226-34. doi: 10.1111/j.1747-0803.2011.00605.x. Epub 2011 Dec 18. PMID: 22176653.
  8. Soriano-Maldonado A, Hidalgo M, Arteaga P, de Pascual-Teresa S, Nova E. Effects of regular consumption of vitamin C-rich or polyphenol-rich apple juice on cardiometabolic markers in healthy adults: a randomized crossover trial. Eur J Nutr. 2014 Dec;53(8):1645-57. doi: 10.1007/s00394-014-0670-7. Epub 2014 Feb 16. PMID: 24531755.
  9. Yamazaki F. Oral vitamin C enhances the adrenergic vasoconstrictor response to local cooling in human skin. J Appl Physiol (1985). 2012 May;112(10):1689-97. doi: 10.1152/japplphysiol.00043.2012. Epub 2012 Mar 1. PMID: 22383508.
  10. Wray DW, Nishiyama SK, Harris RA, Zhao J, McDaniel J, Fjeldstad AS, Witman MA, Ives SJ, Barrett-O'Keefe Z, Richardson RS. [Support for arterial health] in the elderly after antioxidant consumption. Hyp. 2012 Apr;59(4):818-24. doi: 10.1161/HYPERTENSIONAHA.111.189456. Epub 2012 Feb 21. PMID: 22353612; PMCID: PMC3321727.
  11. Romero SA, Ely MR, Sieck DC, Luttrell MJ, Buck TM, Kono JM, Branscum AJ, Halliwill JR. Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans. Exp Physiol. 2015 Apr 1;100(4):435-49. doi: 10.1113/EP085030. Epub 2015 Mar 25. PMID: 25664905; PMCID: PMC4533997.
  12. De Marchi S, Prior M, Rigoni A, Zecchetto S, Rulfo F, Arosio E. Ascorbic acid [promotes arterial function after oral glucose load] in healthy subjects. Eur J Intern Med. 2012 Jan;23(1):54-7. doi: 1016/j.ejim.2011.07.019. Epub 2011 Aug 27. PMID: 22153532.
  13. Mullan BA, Young IS, Fee H, McCance DR. Ascorbic acid [promotes healthy blood pressure and arterial function]. Hypertension. 2002 Dec;40(6):804-9. doi: 10.1161/01.hyp.0000039961.13718.00. PMID: 12468561.
  14. Brody S, Preut R, Schommer K, Schürmeyer TH. A randomized controlled trial of high dose ascorbic acid [to promote healthy] blood pressure, cortisol, and subjective responses to psychological stress. Psychopharmacology (Berl). 2002 Jan;159(3):319-24. doi: 10.1007/s00213-001-0929-6. Epub 2001 Nov 20. PMID: 11862365.
  15. Newsom SA, Paxton RJ, Rynn GM, Bell C. Influence of ascorbic acid on the thermic effect of feeding in overweight and obese adult humans. Obesity (Silver Spring). 2008 Aug;16(8):1749-54. doi: 10.1038/oby.2008.304. Epub 2008 Jun 12. PMID: 18551121.
  16. Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation [to promote healthy blood sugar]. Ann Nutr Metab. 1995;39(4):217-23. doi: 10.1159/000177865. PMID: 8546437.
  17. John JH, Ziebland S, Yudkin P, Roe LS, Neil HA; Oxford Fruit and Vegetable Study Group. Effects of fruit and vegetable consumption on plasma antioxidant concentrations and blood pressure: a randomised controlled trial. Lancet. 2002 Jun 8;359(9322):1969-74. doi: 10.1016/s0140-6736(02)98858-6. PMID: 12076551.
  18. Fotherby MD, Williams JC, Forster LA, Craner P, Ferns GA. Effect of vitamin C on ambulatory blood pressure and plasma lipids in older persons. J Hyp. 2000 Apr;18(4):411-5. doi: 10.1097/00004872-200018040-00009. PMID: 10779091.
  19. Farvid MS, Jalali M, Siassi F, Saadat N, Hosseini M. The impact of vitamins and/or mineral supplementation on [promoting healthy blood pressure ]. J Am Coll Nutr. 2004 Jun;23(3):272-9. doi: 10.1080/07315724.2004.10719370. PMID: 15190052.
  20. Rodrigo R, Prat H, Passalacqua W, Araya J, Bächler JP. Decrease in oxidative stress through supplementation of vitamins C and E is associated with [support for healthy] blood pressure in people …. Clin Sci (Lond). 2008 May;114(10):625-34. doi: 10.1042/CS20070343. PMID: 17999638.
  21. Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF Jr, Vita JA. Effect of ascorbic acid treatment on [arterial function] in people …. Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H528-34. doi: 10.1152/ajpheart.2001.280.2.H528. PMID: 11158948.
  22. Galley HF, Thornton J, Howdle PD, Walker BE, Webster NR. Combination oral antioxidant supplementation [promotes healthy] blood pressure. Clin Sci (Lond). 1997 Apr;92(4):361-5. doi: 10.1042/cs0920361. PMID: 9176034.
  23. Nyyssönen K, Poulsen HE, Hayn M, Agerbo P, Porkkala-Sarataho E, Kaikkonen J, Salonen R, Salonen JT. Effect of supplementation of smoking men with plain or slow release ascorbic acid on lipoprotein oxidation. Eur J Clin Nutr. 1997 Mar;51(3):154-63. doi: 10.1038/sj.ejcn.1600376. PMID: 9076405.
  24. Mullan BA, Ennis CN, Fee HJ, Young IS, McCance DR. Protective effects of ascorbic acid on[artery function and blood flow during blood sugar spike]. Am J Physiol Heart Circ Physiol. 2004 Sep;287(3):H1262-8. doi: 10.1152/ajpheart.00153.2003. Epub 2004 Apr 15. PMID: 15087291.
  25. Ghosh SK, Ekpo EB, Shah IU, Girling AJ, Jenkins C, Sinclair AJ. A double-blind, placebo-controlled parallel trial of vitamin C treatment in [promoting healthy blood pressure in] elderly …. Gerontology. 1994;40(5):268-72. doi: 10.1159/000213595. PMID: 7959083.
  26. Nappo F, De Rosa N, Marfella R, De Lucia D, Ingrosso D, Perna AF, Farzati B, Giugliano D. [Promoting arterial health with] antioxidant vitamins. JAMA. 1999 Jun 9;281(22):2113-8. doi: 10.1001/jama.281.22.2113. PMID: 10367822.
  27. Schindler TH, Magosaki N, Jeserich M, Olschewski M, Nitzsche E, Holubarsch C, Solzbach U, Just H. Effect of ascorbic acid on [coronary arterial function] in chronic smokers assessed by cold pressor testing. Cardiology. 2000;94(4):239-46. doi: 10.1159/000047324. PMID: 11326145.
  28. Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H, Shimazaki S. [Promoting cardiovascular function] in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch Surg. 2000 Mar;135(3):326-31. doi: 10.1001/archsurg.135.3.326. PMID: 10722036.
  29. Kim MK, Sasaki S, Sasazuki S, Okubo S, Hayashi M, Tsugane S. Lack of long-term effect of vitamin C supplementation on blood pressure. Hyp. 2002 Dec;40(6):797-803. doi: 10.1161/01.hyp.0000038339.67450.60. PMID: 12468560.
  30. Young JM, Shand BI, McGregor PM, Scott RS, Frampton CM. Comparative effects of enzogenol and vitamin C supplementation versus vitamin C alone on endothelial function and biochemical markers of oxidative stress and [inflammatory response] in chronic smokers. Free Radic Res. 2006 Jan;40(1):85-94. doi: 10.1080/10715760500329788. Erratum in: Free Radic Res. 2007 Jan;41(1):121. PMID: 16298763.
  31. Duffy SJ, Gokce N, Holbrook M, Huang A, Frei B, Keaney JF Jr, Vita JA. [Promoting healthy blood pressure] with ascorbic acid. Lancet. 1999 Dec 11;354(9195):2048-9. doi: 10.1016/s0140-6736(99)04410-4. PMID: 10636373.
  32. Coppola A, Astarita C, Liguori E, Fontana D, Oliviero M, Esposito K, Coppola L, Giugliano D. [Promoting coronary circulatory health with] antioxidant vitamins. J Intern Med. 2004 Nov;256(5):398-405. doi: 10.1111/j.1365-2796.2004.01389.x. PMID: 15485475.
  33. Miller ER 3rd, Appel LJ, Levander OA, Levine DM. The effect of antioxidant vitamin supplementation on [cardiovascular function]. J Cardiovasc [R]. 1997 Feb;4(1):19-24. doi: 10.1177/174182679700400104. PMID: 9215516.
  34. Hajjar IM, George V, Sasse EA, Kochar MS. A randomized, double-blind, controlled trial of vitamin C [to support healthy blood pressure] and lipids. Am J Ther. 2002 Jul-Aug;9(4):289-93. doi: 10.1097/00045391-200207000-00005. PMID: 12115017.
  35. Schutte AE, Huisman HW, Oosthuizen W, van Rooyen JM, Jerling JC. Cardiovascular effects of oral Supplementation of vitamin C, E and folic acid in young healthy males. Int J Vitam Nutr Res. 2004 Jul;74(4):285-93. doi: 10.1024/0300-9831.74.4.285. PMID: 15580811.
  36. Gülmezoğlu AM, Hofmeyr GJ, Oosthuisen MM. Antioxidants in [promoting healthy blood pressure in pregnant women]: an explanatory randomised controlled trial. Br J Obstet Gynaecol. 1997 Jun;104(6):689-96. doi: 10.1111/j.1471-0528.1997.tb11979.x. PMID: 9197872.
  37. Wright CI, Ruediger H, Kroner CI, Janssen BJ, Draijer R. Acute autonomic effects of vitamins and fats in male smokers. Eur J Clin Nutr. 2009 Feb;63(2):246-52. doi: 10.1038/sj.ejcn.1602912. Epub 2007 Sep 26. PMID: 17895912.
  38. Ceriello A, Giugliano D, Quatraro A, Lefebvre PJ. Anti-oxidants show [support for caridovascular function]. Clin Sci (Lond). 1991 Dec;81(6):739-42. doi: 10.1042/cs0810739. PMID: 1662579.
  39. Stein JH, Carlsson CM, Papcke-Benson K, Aeschlimann SE, Bodemer A, Carnes M, McBride PE. The effects of [antioxidant vitamains on arterial function in older adults]. J Am Coll Cardiol. 2001 Dec;38(7):1806-13. doi: 10.1016/s0735-1097(01)01650-3. PMID: 11738278.
  40. Watanabe H, Kakihana M, Ohtsuka S, Sugishita Y. Randomized, double-blind, placebo-controlled study of ascorbate on [promoting cardiovascular function in patients]. Circulation. 1998 Mar 10;97(9):886-91. doi: 10.1161/01.cir.97.9.886. PMID: 9521337.
  41. Villar J, Purwar M, Merialdi M, Zavaleta N, Thi Nhu Ngoc N, Anthony J, De Greeff A, Poston L, Shennan A; WHO Vitamin C and Vitamin E trial group. World Health Organisation multicentre randomised trial of supplementation with vitamins C and E [to promote healthy blood pressure in pregnant women] in populations of low nutritional status from developing countries. BJOG. 2009 May;116(6):780-8. doi: 10.1111/j.1471-0528.2009.02158.x. PMID: 19432566.
  42. Woodside JV, Yarnell JW, McMaster D, Young IS, Harmon DL, McCrum EE, Patterson CC, Gey KF, Whitehead AS, Evans A. Effect of B-group vitamins and antioxidant vitamins on[cardiovascular function]: a double-blind, randomized, factorial-design, controlled trial. Am J Clin Nutr. 1998 May;67(5):858-66. doi: 10.1093/ajcn/67.5.858. Erratum in: Am J Clin Nutr 1998 Sep;68(3):758. PMID: 9583842.
  43. Muñoz JA, Garcia C, Quilez JL, Andugar MA. Effect of vitamin C on lipoproteins in healthy adults. Ann Med Interne (Paris). 1994;145(1):13-9. PMID: 8192275.
  44. McVeigh GE, Hamilton P, Wilson M, Hanratty CG, Leahey WJ, Devine AB, Morgan DG, Dixon LJ, McGrath LT. Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of supplemental ascorbate. Circulation. 2002 Jul 9;106(2):208-13. doi: 10.1161/01.cir.0000021600.84149.78. PMID: 12105160.
  45. Plotnick GD, Corretti MC, Vogel RA. Effect of antioxidant vitamins on [arterial function] following a single high-fat meal. JAMA. 1997 Nov 26;278(20):1682-6. PMID: 9388088.
  46. Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, Salvetti A. Supplementation with vitamins C and E [promotes arterial health]. Am J Hyp. 2007 Apr;20(4):392-7. doi: 10.1016/j.amjhyper.2006.09.021. PMID: 17386345.
  47. Efstratopoulos AD, Voyaki SM. Effect of anti-oxidants on [blood pressure function in smokers]. J Hypertens Suppl. 1993 Dec;11(5):S112-3. PMID: 8158300.
  48. Lovat LB, Lu Y, Palmer AJ, Edwards R, Fletcher AE, Bulpitt CJ. Double-blind trial of vitamin C [on blood pressure] in elderly. J Hum Hyp. 1993 Aug;7(4):403-5. PMID: 8410936.

Grape Seed and Blood Pressure (8 Clinical Studies)

  1. Kim JK, Kim KA, Choi HM, Park SK, Stebbins CL. Grape Seed Extract Supplementation [Promotes] Blood Pressure Response to Exercise…. J Med Food. 2018 May;21(5):445-453. doi: 10.1089/jmf.2017.0133. Epub 2018 Apr 23. PMID: 29683391.
  2. Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices…: a randomized, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016 Jan 28;115(2):226-38. doi: 10.1017/S0007114515004328. Epub 2015 Nov 16. PMID: 26568249.
  3. Biesinger S, Michaels HA, Quadros AS, Qian Y, Rabovsky AB, Badger RS, Jalili T. A combination of isolated phytochemicals and botanical extracts[promotes healthy blood pressure] in a randomized controlled trial of hypertensive subjects. Eur J Clin Nutr. 2016 Jan;70(1):10-6. doi: 10.1038/ejcn.2015.88. Epub 2015 Jun 10. PMID: 26059745.
  4. Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects…. 2009 Dec;58(12):1743-6. doi: 10.1016/j.metabol.2009.05.030. Epub 2009 Jul 15. PMID: 19608210.
  5. Ras RT, Zock PL, Zebregs YE, Johnston NR, Webb DJ, Draijer R. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects …. Br J Nutr. 2013 Dec;110(12):2234-41. doi: 1017/S000711451300161X. Epub 2013 May 23. PMID: 23702253.
  6. Odai T, Terauchi M, Kato K, Hirose A, Miyasaka N. Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants …. Nutrients. 2019 Nov 20;11(12):2844. doi: 10.3390/nu11122844. PMID: 31757033; PMCID: PMC6950399.
  7. Terauchi M, Horiguchi N, Kajiyama A, Akiyoshi M, Owa Y, Kato K, Kubota T. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause. 2014 Sep;21(9):990-6. doi: 10.1097/GME.0000000000000200. PMID: 24518152.Ward NC, Hodgson JM, Croft KD, Burke V, Beilin LJ, Puddey IB. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens. 2005 Feb;23(2):427-34. doi: 10.1097/00004872-200502000-00026. PMID: 15662232.
  8. Hodgson JM, Croft KD, Woodman RJ, Puddey IB, Bondonno CP, Wu JH, Beilin LJ, Lukoshkova EV, Head GA, Ward NC. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomized controlled trials. Br J Nutr. 2014 Nov 14;112(9):1551-61. doi: 10.1017/S0007114514002542. Epub 2014 Sep 19. PMID: 25234339.

Roselle and Blood Pressure (13 Clinical Trials)

  1. McKay DL, Chen CY, Saltzman E, Blumberg JB. Hibiscus sabdariffa L. tea (tisane) [promotes blood pressure health]. J Nutr. 2010 Feb;140(2):298-303. doi: 10.3945/jn.109.115097. Epub 2009 Dec 16. PMID: 20018807.
  2. Nwachukwu DC, Aneke E, Nwachukwu NZ, Obika LF, Nwagha UI, Eze AA. Effect of Hibiscus sabdariffa on blood pressure and electrolyte profile…. Niger J Clin Pract. 2015 Nov-Dec;18(6):762-70. doi: 10.4103/1119-3077.163278. PMID:
  3. Abubakar SM, Ukeyima MT, Spencer JPE, Lovegrove JA. Acute Effects of Hibiscus Sabdariffa Calyces on Postprandial Blood Pressure, Vascular Function, Blood Lipids, Biomarkers ….. in Humans Nutrients. 2019 Feb 5;11(2):341. doi: 10.3390/nu11020341. PMID: 30764582; PMCID: PMC6412462.
  4. Boix-Castejón M , Herranz-López M , Pérez Gago A , Olivares-Vicente M , Caturla N , Roche E , Micol V . Hibiscus and lemon verbena polyphenols modulate appetite-related biomarkers in overweight subjects: a randomized controlled trial. Food Funct. 2018 Jun 20;9(6):3173-3184. doi: 10.1039/c8fo00367j. Erratum in: Food Funct. 2018 Jul 17;9(7):4037. PMID: 29862395.
  5. Seck SM, Doupa D, Dia DG, Diop EA, Ardiet DL, Nogueira RC, Graz B, Diouf B. Clinical efficacy of African traditional medicines in [promoting blood pressure health]: A randomized controlled trial with Combretum micranthum and Hibiscus sabdariffa. J Hum Hyp. 2017 Dec;32(1):75-81. doi: 10.1038/s41371-017-0001-6. Epub 2017 Oct
    PMID: 29311704.
  6. Mozaffari-Khosravi H, Ahadi Z, Barzegar K. The effect of green tea and sour tea on blood pressure of people …: a randomized clinical trial. J Diet Suppl. 2013 Jun;10(2):105-15. doi: 10.3109/19390211.2013.790333. PMID: 23725524.
  7. Beltrán-Debón R, Rodríguez-Gallego E, Fernández-Arroyo S, Senan-Campos O, Massucci FA, Hernández-Aguilera A, Sales-Pardo M, Guimerà R, Camps J, Menendez JA, Joven J. The acute impact of polyphenols from Hibiscus sabdariffa in metabolic homeostasis: an approach combining metabolomics and gene-expression analyses. Food Funct. 2015 Sep;6(9):2957-66. doi: 10.1039/c5fo00696a. PMID: 26234931.
  8. Haji Faraji M, Haji Tarkhani A. The effect of sour tea (Hibiscus sabdariffa) on [promoting blood pressure health]. J Ethnopharmacol. 1999 Jun;65(3):231-6. doi: 10.1016/s0378-8741(98)00157-3. PMID: 10404421.
  9. Herranz-López M, Olivares-Vicente M, Boix-Castejón M, Caturla N, Roche E, Micol V. Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial. Sci Rep. 2019 Feb 28;9(1):2999. doi: 10.1038/s41598-019-39159-5. PMID: 30816148; PMCID: PMC6395806.
  10. Herrera-Arellano A, Flores-Romero S, Chávez-Soto MA, Tortoriello J. Effectiveness and tolerability of a standardized extract from Hibiscus sabdariffa [in promoting blood pressure health in people ]: a controlled and randomized clinical trial. Phytomedicine. 2004 Jul;11(5):375-82. doi: 10.1016/j.phymed.2004.04.001. PMID: 15330492.
  11. Herrera-Arellano A, Miranda-Sánchez J, Avila-Castro P, Herrera-Alvarez S, Jiménez-Ferrer JE, Zamilpa A, Román-Ramos R, Ponce-Monter H, Tortoriello J. Clinical effects produced by a standardized herbal medicinal product of Hibiscus sabdariffa on [promoting blood pressure health in human ]. A randomized, double-blind, lisinopril-controlled clinical trial. Planta Med. 2007 Jan;73(1):6-12. doi: 10.1055/s-2006-957065. PMID: 17315307.
  12. Mozaffari-Khosravi H, Jalali-Khanabadi BA, Afkhami-Ardekani M, Fatehi F, Noori-Shadkam M. The effects of sour tea (Hibiscus sabdariffa) on [blood pressure health in people ].... J Hum Hypertens. 2009 Jan;23(1):48-54. doi: 10.1038/jhh.2008.100. Epub 2008 Aug 7. PMID: 18685605.
  13. Nwachukwu DC, Aneke EI, Nwachukwu NZ, Azubike N, Obika LF. Does consumption of an aqueous extract of Hibscus sabdariffa affect renal function …? J Physiol Sci. 2017 Jan;67(1):227-234. doi: 10.1007/s12576-016-0458-z. Epub 2016 May 24. PMID: 27221151.

Garlic and Blood Pressure (16 Human Clinical Trials)

  1. Zeb F, Safdar M, Fatima S, Khan S, Alam S, Muhammad M, Syed A, Habib F, Shakoor H. Supplementation of garlic and coriander seed powder: Impact on body mass index, lipid profile and blood pressure…. Pak J Pharm Sci. 2018 Sep;31(5):1935-1941. PMID: 30150192.
  2. Ried K, Frank OR, Stocks NP. Aged garlic extract [promotes blood pressure health]: a dose-response trial. Eur J Clin Nutr. 2013 Jan;67(1):64-70. doi: 10.1038/ejcn.2012.178. Epub 2012 Nov 21. PMID: 23169470; PMCID: PMC3561616.
  3. Ashraf R, Khan RA, Ashraf I, Qureshi AA. Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in people …. Pak J Pharm Sci. 2013 Sep;26(5):859-63. PMID: 24035939.
  4. Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in people …: a randomized controlled trial. Maturitas. 2010 Oct;67(2):144-50. doi: 10.1016/j.maturitas.2010.06.001. Epub 2010 Jul 1. PMID: 20594781.
  5. Choudhary PR, Jani RD, Sharma MS. Effect of Raw Crushed Garlic (Allium sativum L.) on [Promoting Blood Sugar Health]. J Diet Suppl. 2018 Jul 4;15(4):499-506. doi: 10.1080/19390211.2017.1358233. Epub 2017 Sep 28. PMID: 28956671.
  6. Capraz M, Dilek M, Akpolat T. Garlic, [blood pressure health] and patient education. Int J Cardiol. 2007 Sep 14;121(1):130-1. doi: 10.1016/j.ijcard.2006.08.060. Epub 2006 Nov 7. PMID: 17088002.
  7. Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. Time-released garlic powder tablets [promote blood pressure health in men]. Hyp Res. 2009 Jun;32(6):433-7. doi: 10.1038/hr.2009.36. Epub 2009 Apr 24. PMID: 19390538.
  8. Turner B, Mølgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial [health]: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004 Oct;92(4):701-6. doi: 10.1079/bjn20041255. PMID: 15522140.
  9. Auer W, Eiber A, Hertkorn E, Hoehfeld E, Koehrle U, Lorenz A, Mader F, Merx W, Otto G, Schmid-Otto B, et al. [Blood pressure and blood lipid health]: garlic helps in mild cases. Br J Clin Pract Suppl. 1990 Aug;69:3-6. PMID: 2083170.
  10. Holzgartner H, Schmidt U, Kuhn U. Comparison of the efficacy and tolerance of a garlic preparation …. Arzneimittelforschung. 1992 Dec;42(12):1473-7. PMID: 1288512.
  11. Budoff MJ, Ahmadi N, Gul KM, Liu ST, Flores FR, Tiano J, Takasu J, Miller E, Tsimikas S. Aged garlic extract supplemented with B vitamins, folic acid and L-arginine [promotes arterial health]: a randomized clinical trial. Prev Med. 2009 Aug-Sep;49(2-3):101-7. doi: 1016/j.ypmed.2009.06.018. Epub 2009 Jun 30. PMID: 19573556.
  12. Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E. Effect of garlic on [cardiovascular health]. Int J Clin Pharmacol Ther Toxicol. 1991 Apr;29(4):151-5. PMID: 2071264.
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Ashwagandha and Sleep (6 Human Clinical Trials)

  1. Langade D, Kanchi S, Salve J, Debnath K, Ambegaokar D. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in promoting sleep quality and calmness…: A Double-blind, Randomized, Placebo-controlled Study. Cureus. 2019 Sep 28;11(9):e5797. doi: 10.7759/cureus.5797. PMID: 31728244; PMCID: PMC6827862.
  2. Salve J, Pate S, Debnath K, Langade D. Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study. Cureus. 2019 Dec 25;11(12):e6466. doi: 10.7759/cureus.6466. PMID: 32021735; PMCID: PMC6979308.
  3. Kelgane SB, Salve J, Sampara P, Debnath K. Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study. Cureus. 2020 Feb 23;12(2):e7083. doi: 10.7759/cureus.7083. PMID: 32226684; PMCID: PMC7096075.
  4. Raut AA, Rege NN, Tadvi FM, Solanki PV, Kene KR, Shirolkar SG, Pandey SN, Vaidya RA, Vaidya AB. Exploratory study to evaluate tolerability, safety, and activity of Ashwagandha (Withania somnifera) in healthy volunteers. J Ayurveda Integr Med. 2012 Jul;3(3):111-4. doi: 10.4103/0975-9476.100168. PMID: 23125505; PMCID: PMC3487234.
  5. Langade D, Thakare V, Kanchi S, Kelgane S. Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers…: A double-blind, randomized, parallel-group, placebo-controlled study. J Ethnopharmacol. 2020 Aug 17;264:113276. doi: 10.1016/j.jep.2020.113276.
  6. Deshpande A, Irani N, Balkrishnan R, Benny IR. A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults. Sleep Med. 2020 Aug;72:28-36. doi: 10.1016/j.sleep.2020.03.012. Epub 2020 Mar 21. PMID: 32540634.

Ashwagandha and Stress (7 Human Clinical Trials)

  1. Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. doi: 10.1097/MD.0000000000017186. PMID: 31517876; PMCID: PMC6750292.
  2. Choudhary D, Bhattacharyya S, Joshi K. Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract: A Double-Blind, Randomized, Placebo-Controlled Trial. J Evid Based Complementary Altern Med. 2017 Jan;22(1):96-106. doi: 10.1177/2156587216641830. Epub 2016 Apr 6. PMID: 27055824; PMCID: PMC5871210.
  3. Deshpande A, Irani N, Balakrishnan R. Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep. Medicine (Baltimore). 2018 Jun;97(26):e11299. doi: 10.1097/MD.0000000000011299. PMID: 29953014; PMCID: PMC6039614.
  4. Gannon JM, Brar J, Rai A, Chengappa KNR. Effects of a standardized extract of Withania somnifera (Ashwagandha) [on mood] … in a randomized, placebo-controlled clinical trial. Ann Clin Psychiatry. 2019 May;31(2):123-129. PMID: 31046033.
  5. Chengappa KN, Bowie CR, Schlicht PJ, Fleet D, Brar JS, Jindal R. Randomized placebo-controlled adjunctive study of an extract of withania somnifera [cognition]…. J Clin Psychiatry. 2013 Nov;74(11):1076-83. doi: 10.4088/JCP.13m08413. PMID: 24330893.
  6. Cooley K, Szczurko O, Perri D, Mills EJ, Bernhardt B, Zhou Q, Seely D. Naturopathic care for [mood health]: a randomized controlled trial ISRCTN78958974. PLoS One. 2009 Aug 31;4(8):e6628. doi: 10.1371/journal.pone.0006628. PMID: 19718255; PMCID: PMC2729375.
  7. Fuladi S, Emami SA, Mohammadpour AH, Karimani A, Manteghi AA, Sahebkar A. Assessment of Withania somnifera root extract efficacy [on mood health] in …: A randomized double-blind placebo-controlled trial. Curr Clin Pharmacol. 2020 Apr 13. doi: 10.2174/1574884715666200413120413. Epub ahead of print. PMID: 32282308.